In recent years, the mortality of cultured grouper with typical signs of SGD has occurred frequently in Cam Ranh, Cam Lam and Van Ninh areas (Khanh Hoa province). The cumulative mortality is up to 70% of the population of cultured grouper. Test results by Elisa showed that the fish was positive for Iridovirus. The research team of the CAAHBS has conducted a study to evaluate the protective efficiency of Piscivac Irido Si vaccine against SGD caused by Iridovirus. Previously, the Piscivac Irido Si vaccine has been used to prevent disease caused by Iridovirus on seabass in Vietnam since 2019.

Experimental results show that the relative protection coefficient of Piscivac Irido Si vaccine against disease caused by Iridovirus in grouper is 72.9%, Piscivac Irido Si vaccine is completely safe for hybrid grouper.

In Vietnam, grouper has been cultured for a long time, but so far, grouper farming has not developed strongly due to many different reasons, disease is one of the important ones. Iridovirus causing SGD usually occurs in grouper fingerling and grow-out stage. The typical sign of SGD is that grouper usually dies in the evening or early morning without any sign of damage on the body surface. Currently, there is no cure for SGD in grouper, so vaccination is still the most effective method to limit the damage from this disease.